16 - 17 We sought to evaluate the thoracic aortic diameters in a large population of patients without known diseases to establish normals based on age and gender using high resolution cardiac computed tomography.ġ442 consecutive subjects who were referred for evaluation of possible coronary artery disease underwent coronary CT angiography (CTA) and coronary artery calcium scanning (CACS), mean age 55+11 years, 65% male ( table 1). To date, most CT studies which evaluated the thoracic aorta diameters in adults have been small in size. 12 - 17 With more application of cardiac CT and thoracic CT, it is essential to define the normal thoracic aortic diameter changes with aging in both genders. There has been some reports of the importance of aging on this process and gender related differences in aortic diameters. 11 Early detection of aortic atherosclerosis before the onset of clinical symptoms may improve both the diagnosis and therapeutic interventions. Aortic root changes due to aging, involving aortic distensibility, is the most common cause of aortic regurgitation. Ascending aortic atherosclerosis has also been associated with aortic valve disease, Marfan syndrome, and aortic aneurysms. Atherosclerotic disease of the aorta has been demonstrated to increase the risk for ischemic stroke 1 - 5, and been demonstrated to be associated with coronary artery disease (CAD) 6 - 10. AAOD was 1.7 mm less in end-diastole than end systole(P<0.001).Ītherosclerosis is a generalized process that may involve the aorta as well as the coronary arteries. The reproducibility, wall thickness and difference between end systole and diastole were calculated.ĪAOD has significant linear association with age, gender, descending aortic diameter and pulmonary artery diameter (P0.91, P<0.001, coefficient variation <3.2%). The linear correlation analysis was done between AAOD and all parameters. The mean value and age specific and gender adjusted upper normal limits (mean + 2 standard deviations) were calculated. Patients demographic information, age, gender, weight, height and body surface area (BSA), were recorded. The volume of four chambers, ejection fraction of left ventricle, and cardiac output were measured in 56% of the patients. The ascending aortic diameter, descending aortic diameter (DAOD), pulmonary artery (PAD) and chest anterioposterior diameter (CAPD), posterior border of sternal bone to anterior border of spine, were measured at the slice level of mid right pulmonary artery by using end systolic trigger image. 1442 consecutive subjects who were referred for evaluation of possible coronary artery disease underwent coronary CT angiography (CTA) and coronary artery calcium scanning (CACS) (55+11 years, 65% male) without known coronary heart disease, hypertension, chronic pulmonary and renal disease, diabetes and severe aortic calcification.
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